Mellough CB, Collin J, Queen R, Hilgen G, Dorgau B, Zerti D, Felemban M, White K, Sernagor E, Lako M. Stem Cells Transl Med. 2019 Mar 27. doi: 10.1002/sctm.18-0267. [Epub ahead of print].

Dorgau B, Felemban M, Hilgen G, Kiening M, Zerti D, Hunt NC, Doherty M, Whitfield P, Hallam D, White K, Ding Y, Krasnogor N, Al-Aama J, Asfour HZ, Sernagor E, Lako M. Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids. Biomaterials. 2019 Apr;199:63-75. doi: 10.1016/j.biomaterials.2019.01.028. Epub 2019 Jan 22.

Collin J, Queen R, Zerti D, Dorgau B, Hussain R, Coxhead J, Cockell S and Lako M. Deconstructing Retinal Organoids: Single cell RNA-Seq reveals the cellular components of human pluripotent stem cell-derived retina. Stem Cells. 2018 Dec 12. doi: 10.1002/stem.2963. [Epub ahead of print]

Mellough CB, Bauer R, Collin J, Dorgau B, Zerti D, Dolan D, Jones CM, Izuogu OG, Yu M, Hallam D, Steyn JS, White K, Steel DH, Santibanez-Koref M, Elliott DJ, Jackson MS, Lindsay S, Grellscheid S and Lako M. An integrated transcriptional analysis of the developing human retina. Development. 2019 Jan 29;146(2). pii: dev169474. doi: 10.1242/dev.169474

Collin J, Zerti D, Queen R, Santo-Ferreira T, Coxhead J, Hussain R, Steel D, Mellough C, Ader M, Sernagor E, Armstrong L and Lako M. CRX expression in pluripotent stem cell derived photoreceptors marks a transplantable subpopulation of early cones. Stem Cells (in press). [Epub ahead of print]

A, Zhu, L, Chichagova V, Basu B, Mozafari-Jovin S et al, Luehrmann R, Grellscheid SN, Johnson CA and Lako M. Splicing factor PRPF31 retinitis pigmentosa (RP11) is caused by disrupted alternative splicing programmes for genes implicated in pre-mRNA splicing, cellular adhesion and ciliogenesis. Nature Communications 2018; 9(1):4234. doi: 10.1038/s41467-018-06448-y. (

Hallam D, Hilgen G, Dorgau B, Zhu L, Yu M, Bojic S, Hewitt P, Schmitt M, Uteng M, Kustermann S, Steel D, Nicholds M, Thomas R, Treumann A, Porter A, Sernagor E, Armstrong L, Lako M. Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency. Stem Cells. 2018 Jul 13. doi: 10.1002/stem.2883. Stem Cells. 2018 Jul 13. doi: 10.1002/stem.2883.

Special Series: Transplantation of Stem Cells into the Eye. Lako M. Stem Cells. 2018 Aug 22. doi: 10.1002/stem.2896. [Epub ahead of print] No abstract available.

Felemban M, Dorgau B, Hunt NC, Hallam D, Zerti D, Bauer R, Ding Y, Collin J, Steel D, Krasnogor N, Al-Aama J, Lindsay S, Mellough C, Lako M. Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix. Acta Biomater. 2018 Jul 1;74:207-221. doi: 10.1016/j.actbio.2018.05.023.

Dorgau B, Felemban M, Sharpe A, Bauer R, Hallam D, Steel DH, Lindsay S, Mellough C, Lako M. Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation. Cell Death Dis. 2018 May 23;9(6):615. doi: 10.1038/s41419-018-0648-0.

Chichagova V, Hallam D, Collin J, Zerti D, Dorgau B, Felemban M, Lako M, Steel DH. Cellular regeneration strategies for macular degeneration: past, present and future. Eye (Lond). 2018 May;32(5):946-971. doi: 10.1038/s41433-018-0061-z. Epub 2018 Mar 5. Review.

Hunt NC, Hallam D, Chichagova V, Steel DH, Lako M.Adv Healthc Mater. The Application of Biomaterials to Tissue Engineering Neural Retina and Retinal Pigment Epithelium. 2018 Sep 2:e1800226. doi: 10.1002/adhm.201800226. [Epub ahead of print] Review.

Megaw E, Abu-Arafeh H, Mellough C, Gurniak-Witke C, Witke W, Dhillon B, Wright AF, Lako M and Ffrench-Constant C. (2017) Human induced pluripotent stem cell and animal models of X-linked retinitis pigmentosa identify impaired gelsolin activation as a cause of photoreceptor loss. Nature Communications: 8:271.

Chichagova V, Hallam D, Collin J, Buskin A, Saretzki G, Armstrong L, Yu-Man P, Lako M and Steel D (2017) Human iPSC disease modelling reveals functional and structural defects in retinal pigment epithelial cells harbouring the m.3243A>G mitochondrial DNA mutation. Scientific Reports 26: 12320.

Hallam D, Collin J, Bojic S, Chichagova V, Buskin A, Yu X, Lafage L, Otten EG, Anyfantis G, Mellough C, Przyborski S, Alharthi S, Korolchuk V, Lotery A, Saretzki G, McKibbin M, Armstrong L, Steel D, Lako M. (2017) An iPSC patient specific model of CFH (Y402H) polymorphism displays characteristic features of AMD and indicates a beneficial role for UV light exposure. Stem Cells 35: 2305-2320.

Hunt NC, Hallam D, Karimi A, Mellough CB, Steel DHW and Lako M. (2017) 3D culture of human pluripotent stem cells in RGD - alginate hydrogel improves retinal tissue development. Acta Biomaterilia 49: 329-343..

Zhu L, Gomez A, Saretzki G, Jin S, Tilgner K, Melguzo-Sanchiz D, Anyfantis G, Al-Aama J, Vallier L, Chinnery P, Lako M and Armstrong L (2016) CHCHD2 primes the differentiation potential of human induced pluripotent stem cells to neuroectodermal lineages. J. Cell Biology 215(2):187-202.

Collin J, Mellough CB, Do rgau B, Pryzborki S, Moreno-Gimeno I and Lako M (2016) Using zinc finger nuclease technology to generate CRX-GFP reporter human embryonic stem cells as a tool to identify and study the emergence of photoreceptor precursors during pluripotent stem cell differentiation. Stem Cells 34: 311-21 (Cover page image)

Mellough CB and Lako M (2016) How to build a human. Elife. 24;5. pii: e19826.

Hunt NC and Lako M (2016) Tissue engineering using pluripotent stem cells: multidisciplinary approaches to accelerate bench-to-bedside transition. Regen Med. 6:495-8.

Chichagova V, Sanchez-Vera I, Armstrong L, Steel D, Lako M. (2016) Generation of Human Induced Pluripotent Stem Cells Using RNA-Based Sendai Virus System and Pluripotency Validation of the Resulting Cell Population. Methods Mol Biol. 1353:285-307.

Mellough CB, Collin J, Khazim M, White K, Sernagor E, Steel D and Lako M (2015) IGF-1 signalling plays an important role in the formation of three dimensional laminated neural retina and other ocular structures from human embryonic stem cells. Stem Cells 33:2416-30 (Cover page image)

Megaw R, Mellough C, WRIGHT A, Lako M and Ffrench-Constant C (2015) Use of induced pluripotent stem cells technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa. Lancet Suppl 1:S69. doi: 10.1016/S0140-6736(15)60384-1.

Mellough CB, Collin J, Sernagor E, Wride NK, Steel DH and Lako M (2014) Lab generated retina: Realising the dream. Vision Neuroscience 22:1-16 (cover page image selected from our work described in this review).

Mellough CB, Sernagor E, Moreno-Gimeno, I, Steel DHW and Lako M (2012) Efficient stage-specific differentiation of human pluripotent stem cells towards retinal photoreceptor cells. Stem Cells 30:673-86 9 (front cover).

Armstrong L, Lako M, Buckley N, Lappin TR, Murphy MJ, Nolta JA, Pittenger M, Stojkovic M (2012). Editorial: Our top 10 developments in stem cell biology over the last 30 years. Stem Cells. 30:2-9.

Collin J, Lako M. (2011) Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells. Stem Cells. 29:1021-33.

Armstrong L, Tilgner K, Saretzki G, Atkinson SP, Stojkovic M, Moreno R, Przyborski S, Lako M.(2010) Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells. Stem Cells. 28:661-73.

Lako M, Armstrong L, Stojkovic M (2010). Induced pluripotent stem cells : it looks simple but can looks deceive? Stem Cells.28:845-50.

Mellough CB, Steel DH, Lako M. (2009) Genetic basis of inherited macular dystrophies and implications for stem cell therapy. Stem Cells. 27(11):2833-45.

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